Rejuran, RE20, and Prof5ilo are three injectable skin boosters that often get compared, but have different uses. Rejuran uses polynucleotides to signal cellular repair. Prof5ilo uses a high concentration of hyaluronic acid to hydrate and bio-remodel. RE20 supplies dermal matrix proteins as a structural scaffold.
This article explains how each works and how a licensed doctor decides which one, or which combination, may suit a given person. It does not crown a winner, because there isn't a universal one.
Why do these three keep coming up together?
All three are marketed in Singapore for "skin quality": firmer, smoother, more hydrated skin without surgery or fillers. That shared promise is why patients line them up against each other. But the useful question is not which is best, but what problem am I actually trying to solve.
Rejuran
Repair through polynucleotides
Rejuran's active ingredient is polynucleotides (PN), purified from salmon DNA. These fragments are biocompatible with human tissue and work by signalling your skin cells towards repair and regeneration. They encourage fibroblast activity, support the skin barrier, and help calm inflammation.
- What it targets
- Texture, inflammation, irritation, poor quality and hydration, enlarged-looking pores, oiliness, and skin that feels damaged or reactive.
- Who a doctor may consider it for
- Those wanting all round skin quality improvement, cellular repair and resilience rather than added volume. Your skin, but younger.
- What to expect
- Typically three to four sessions about four weeks apart, with mild "mosquito-bite" bumps that settle within a few days. Improvements build gradually over several weeks and sessions, with effects lasting around six months per course.
Think of Rejuran as an instruction to your skin to repair itself.
See the related treatment at Reborn
Prof5ilo
Hydrate and bio-remodel through hyaluronic acid
Prof5ilo is built around a very high concentration of hyaluronic acid, combining high and low molecular weight forms through a heat-based process with no chemical cross-linking. Spread across the tissue, it draws in water for strong hydration. It may also gently stimulate collagen and elastin, which the manufacturer calls "bio-remodelling". It is not a filler. It does not add structured volume; it improves overall skin quality.
- What it targets
- Skin laxity, crepiness, dryness, and dullness.
- Who a doctor may consider it for
- Adults, often from their thirties onward, whose main issues are hydration and early looseness.
- What to expect
- Usually two sessions about a month apart, with mild swelling at the injection points that settles within a day or two. Results tend to last around twelve months per course.
Think of Prof5ilo as deep skin hydration plus a remodelling nudge.
See the related treatment at RebornRe2O
Structural restoration and rebuilding
Re2O (also written RE20) is the newest of the three and works differently. It is made from human acellular dermal matrix (hADM), which is processed purified dermal tissue, mostly collagen and elastin, with the donor cells removed. Injected into the dermis, it supplies a ready-made scaffold that fibroblasts can build around.
- What it targets
- Structural improvement of the skin layer, tightening, loss of elasticity, acne scars, thin and tired worn skin, rough texture, enlarged-looking pores, and skin that has plateaued on other boosters.
- Who a doctor may consider it for
- Adults whose structural scaffolding has thinned and who want matrix support rather than only hydration or signalling.
- What to expect
- Often three sessions about four weeks apart, with mild redness or swelling settling within 24 to 48 hours.
Think of RE20 as supplying the building material itself — restoring your skin with skin-building blocks.
See the related treatment at RebornSide by side: the key differences
| Rejuran | Prof5ilo | RE20 | |
|---|---|---|---|
| Active ingredient | Polynucleotides (PN/PDRN) | High-concentration hyaluronic acid | Human acellular dermal matrix |
| Core mechanism | Cellular repair / signalling | Hydration / bio-remodelling | Structural matrix supplementation |
| Often considered for | Texture, pores, oiliness, sensitive skin | Laxity, dryness, dullness | Elasticity, texture, density |
| Initial sessions | 3 to 4, monthly | 2, monthly | 3, monthly |
| Typical duration | ~6 months | ~12 months | ~6 to 12 months |
| Downtime | 24 to 48h (small bumps) | 24 to 48h (mild swelling) | 24 to 48h (mild swelling) |
| Evidence base | Established | Established | Emerging |
How does a doctor decide which is right for you?
This is where a consultation earns its place. At Reborn Skin Clinic, our doctor looks at several things before suggesting one of these, or a combination:
Your primary concern
Hydration and laxity point one way, repair and texture another, structural elasticity another.
The state of your skin barrier
Reactive or damaged skin may respond differently than robust skin.
Your age and degree of ageing
Early changes are managed differently from more established laxity.
What you have tried before
A plateau on other skin or hydrating boosters may shift the conversation toward a different mechanism.
Your lifestyle
Your tolerance for downtime and repeat sessions matters to whether a plan is realistic.
Can they be combined?
Often, yes, and this is one of the most common questions patients ask. Because the three work through different mechanisms, a doctor may stage them. For example, using one to repair or hydrate and another to support structure, spaced appropriately rather than stacked on the same day. Whether that makes sense for you, and in what order, is a clinical decision made at consultation, not a default.
The honest takeaway is that there is rarely a single correct answer. The point of seeing a doctor is to match the mechanism to your skin, instead of choosing a product by its reputation.
Frequently asked questions
What is the main difference between Rejuran and Prof5ilo?
Rejuran uses polynucleotides to signal cellular repair and is often considered for texture, pores, and damaged or sensitive skin. Prof5ilo uses a high concentration of hyaluronic acid to hydrate and bio-remodel, and is often considered for laxity and dryness. They address different concerns, so a licensed doctor helps determine which fits your skin.
How does Re2O compare to Rejuran and Prof5ilo?
Re2O supplies dermal matrix proteins as a structural scaffold, whereas Rejuran signals repair and Prof5ilo hydrates and remodels. Re2O has been excellent so far, despite being the newer of the three, with a younger independent evidence base; however similar products that Re2O is derived from have a long, excellent track record in surgical and wound reconstruction. A doctor can advise whether it suits your concern.
Can Re2O, Rejuran and Prof5ilo be done together?
Yes. In many cases they can be used as part of a staged plan, since they work differently. The scheduling and order can be discussed with the doctor based on your needs.
How many sessions of a skin booster will I need?
It depends on the product and your skin. As a general guide, Rejuran is often three to four sessions, Prof5ilo two, and RE20 three to begin with, each followed by maintenance. Your exact plan is confirmed at consultation.
Which skin booster is best for sensitive or acne-prone skin?
Polynucleotide-based treatments like Rejuran are frequently discussed for reactive or damaged skin because of their repair and barrier-supporting action, but suitability still depends on an individual assessment by a licensed doctor.